This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fine, D. Articles by Schochetman, G. Search for Related Content PubMed PubMed Citation Articles by Fine, D. Articles by Schochetman, G.

Type D Primate Retroviruses: A Review¹

Viral Oncology Program, Frederick Cancer Research Center, Frederick, Maryland 21701

The prototype virus of the type D retroviruses is the Mason-Pfizer monkey virus (MPMV). MPMV was originally isolated from a breast carcinoma of a female rhesus monkey (an Old World monkey). MPMV is of obvious importance in that it is the only retrovirus thus far isolated from a mammary tumor of a primate and has been shown to have transforming potential for primate cells in vitro. Subsequent to the isolation of MPMV, viruses morphologically and immunologically indistinguishable from MPMV have been isolated from normal placenta and lactating mammary glands of other rhesus monkeys in captivity. Recently, viruses morphologically resembling MPMV have been isolated from a langur monkey (another Old World monkey) and from squirrel monkeys (a New World monkey). Based on nucleic acid hybridization studies, the latter 2 viruses represent endogenous viruses in their species of origin, whereas MPMV appears to be a horizontally transmitted virus containing gene sequences partially related to the langur monkey isolate. Studies on the immunological relatedness of the type D retroviruses have demonstrated interspecies cross-reactivities between the major internal and external proteins of the viruses. Furthermore, these viruses also share cross-reactivity of their major external glycoproteins with those of the type C baboon endogenous virus. These interspecies reactivities can also be demonstrated in natural sera from both imported and laboratory-bred monkeys. The demonstration of these interspecies cross-reactivities shared by distantly related primate retroviruses provides a means for detecting determinants that are representative of all primate retroviruses presently known and yet to be isolated and may provide new assays for detection of a human retrovirus.

¹ This work was supported by the Virus Cancer Program, Contract NO1-CO-75380, National Cancer Institute, NIH, Bethesda, Md. 20014.

Received 4/ 5/78. Accepted 6/16/78.

This article has been cited by other articles:

				C. Voisset, R. A. Weiss, and D. J. Griffiths Human RNA "Rumor" Viruses: the Search for Novel Human Retroviruses in Chronic Disease Microbiol. Mol. Biol. Rev., March 1, 2008; 72(1): 157 - 196. [Abstract] [Full Text] [PDF]

				D. M. Duelli, S. Hearn, M. P. Myers, and Y. Lazebnik A primate virus generates transformed human cells by fusion J. Cell Biol., November 7, 2005; 171(3): 493 - 503. [Abstract] [Full Text] [PDF]

				Y. G. Kuznetsov, S. Datta, N. H. Kothari, A. Greenwood, H. Fan, and A. McPherson Atomic Force Microscopy Investigation of Fibroblasts Infected with Wild-Type and Mutant Murine Leukemia Virus (MuLV) Biophys. J., December 1, 2002; 83(6): 3665 - 3674. [Abstract] [Full Text] [PDF]

				G. J. Baillie and R. J. Wilkins Endogenous Type D Retrovirus in a Marsupial, the Common Brushtail Possum (Trichosurus vulpecula) J. Virol., March 1, 2001; 75(5): 2499 - 2507. [Abstract] [Full Text]

				S. D. Parker and E. Hunter A Cell-Line-Specific Defect in the Intracellular Transport and Release of Assembled Retroviral Capsids J. Virol., January 1, 2000; 74(2): 784 - 795. [Abstract] [Full Text]

				J. B. Bowzard, R. P. Bennett, N. K. Krishna, S. M. Ernst, A. Rein, and J. W. Wills Importance of Basic Residues in the Nucleocapsid Sequence for Retrovirus Gag Assembly and Complementation Rescue J. Virol., November 1, 1998; 72(11): 9034 - 9044. [Abstract] [Full Text] [PDF]

				M. Power, P. Marx, M. Bryant, M. Gardner, P. Barr, and P. Luciw Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus Science, March 28, 1986; 231(4745): 1567 - 1572. [Abstract] [PDF]

				P. Marx, D. Maul, K. Osborn, N. Lerche, P Moody, L. Lowenstine, R. Henrickson, L. Arthur, R. Gilden, M Gravell, et al. Simian AIDS: isolation of a type D retrovirus and transmission of the disease Science, March 9, 1984; 223(4640): 1083 - 1086. [Abstract] [PDF]