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Accelerated Growth of Mammary Tumor Cells in Normal and Athymic Mice after Treatment in Vitro with Dexamethasone¹

Cancer Center of Hawaii, Honolulu, Hawaii 96822

The tumorigenicity of dexamethasone-treated tissuecultured mammary tumor cells was compared to that of untreated mammary tumor cells. The dexamethasone-induced cells progressed faster in normal syngeneic animals than did untreated mammary tumor cells. The fact that the growth rate differential was also observed in athymic mice suggests that T-lymphocyte-mediated immunity was not a factor in the accelerated progression in vivo of the tumor cells that had been cultured in the presence of dexamethasone.

¹ This work was supported by USPHS Grant CA-15655.

Received 1/23/78. Accepted 7/ 5/78.