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Spontaneous Esophageal Carcinoma and Epithelial Cell Line of an Adult Rhesus Monkey¹

Viral Oncology Program, Frederick Cancer Research Center, Frederick, Maryland 21701 [H. R., R. H. N., M. A. G., H. P. C.], Cell Culture Laboratory, University of California School of Public Health, Naval Sciences Laboratory, Oakland, California 94625 [W. A. N-R.], and Litton Bionetics, Inc., Kensington, Maryland 20795 [M. G. V.]

A continuous epithelial cell line, 816A, was established from a lymph node of an adult rhesus monkey with metastatic esophageal carcinoma. These cells are characterized by the presence of desmosomes and a markedly heteroploid karyotype. At a relatively early culture age, electron microscopy showed both budding and extracellular type C virus. Antigen reactive with antisera to Mason-Pfizer monkey virus was observed by complement-fixation. The level of this antigen decreased with increased culture age. To our knowledge, the 816A cells represent the only established simian or human cell line of esophageal carcinoma origin.

¹ This work was supported in part by the Virus Cancer Program Contracts NO1-CO-75380, NO1-CP-33237, and NO1-CP-61006 from the National Cancer Institute, NIH, Bethesda, Md. 20014.

² To whom requests for reprints should be addressed.

Received 5/10/78. Accepted 7/ 7/78.

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				H Rabin, C. Benton, M. Tainsky, N. Rice, and R. Gilden Isolation and characterization of an endogenous type C virus of rhesus monkeys Science, May 25, 1979; 204(4395): 841 - 842. [Abstract] [PDF]