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Heterogeneity and Variability of Artificial Lung Colony-forming Ability among Clones from Mouse Fibrosarcoma¹

Section of Experimental Radiotherapy, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77030

Lung colony-forming ability of clones isolated from a fibrosarcoma was examined by i.v. injection of the cells cultured in vitro. The clones were heterogeneous in their lung colony-forming ability, demonstrating variability of this malignant characteristic.

¹ This investigation was supported in part by Research Grants CA-06294 and CA-11138, awarded by the National Cancer Institute, Department of Health, Education, and Welfare. Animals used in this study were maintained in facilities approved by the American Association for Accreditation of Laboratory Animal Care, and in accordance with current United States Department of Agriculture and Department of Health, Education, and Welfare, NIH regulations and standards.

Received 2/10/78. Accepted 7/11/78.

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