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Natural History of Papillary Lesions of the Urinary Bladder in Schistosomiasis¹

Department of Parasitology [R. E. K., J. A. M., T. C. H.], Southwest Foundation for Research and Education, San Antonio, Texas 78284; Laboratory of Parasitic Diseases [A. W. C.], National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014; and Department of Human Oncology [G. T. B.], University of Wisconsin Center for Health Sciences, Madison, Wisconsin

Variable epithelial hyperplasia was observed in urinary bladder of nine capuchin monkeys (Cebus apella) when examined at cystotomy 94 to 164 weeks after infection with Schistosoma haematobium. These hosts were followed for 24 to 136 weeks postcystotomy to determine the status of bladder lesions in relation to duration of infection and to ascertain whether lesion samples removed at cystotomy reestablished themselves in autologous and heterologous transfers. There was involution of urothelial hyperplasia in eight of nine animals and no evidence for establishment of transplanted bladder lesions.

¹ This investigation was supported by the United States-Japan Cooperative Medical Sciences Program administered by the National Institute of Allergy and Infectious Diseases by Grants CA-13208, CA-16378, and CA-16972 from the National Cancer Institute and, in part, by Grants CA-10017 and CA-14520 from the National Cancer Institute to the University of Wisconsin.

² To whom requests for reprints should be addressed, at the Department of Paristology, Southwest Foundation for Research and Education, San Antonio, Texas 78284.