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Changes in the Composition of Sulfated Mucopolysaccharides during Neoplastic Transformation of Cerebral Tissue¹

Departamento de Bioquimica e Farmacologia, Escola Paulista de Medicina, C. P. 20372, 01000 Sao Paulo, SP, Brazil

The sulfated mucopolysaccharide composition of seven gliomas compared with the sulfated mucopolysaccharide composition of normal cerebral tissues is reported. In all tumors a significantly higher amount of chondroltin sulfate C was found, which is nearly absent in normal brain tissues. The increase of this compound is accompanied by a decrease of chondroitin 4-sulfate in the tumors. The role of chondroitin 6-sulfate in neoplastic transformation is discussed in view of these and other findings.

¹ Aided by grants from Financiadora de Estudos e Projetos, Fundação de Amparo à Pesquisa do Estudo de São Paulo, and Conselho Nacional de Desenvolvimento Científico e Tecnológico.

² From the Hospital das Clínicas, Department of Neurology, Universidade de São Paulo, Brazil.

Received 1/16/78. Accepted 7/24/78.