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Destruction of Regional Lymph Node Metastases of Rat Mammary Adenocarcinoma 13762A by Treatment with Corynebacterium parvum¹

Departments of Pathology [J. W. K., G. L. B., S. W.] and Microbiology [J. W. K., G. L. B.] and Specialized Cancer Research Center, College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania 17033, and the Department of Pathology, School of Medicine, University of Maryland Hospital, Baltimore, Maryland 21201 [D. M. P.]

Intratumoral administration of Corynebacterium parvum to 13762A tumor-bearing rats on Day 7 of tumor growth, followed by primary tumor excision on Day 20, regularly cured about 40% of the animals and significantly prolonged survival in the remainder. Rats treated by surgery alone on either Day 7 or Day 20 died with metastases to axillary lymph nodes and lungs. Tumor was established in axillary lymph nodes by Day 7. Therefore, intratumoral injection of C. parvum on Day 7 destroyed metastases already established at this site. Growth of tumor in axillary nodes of rats treated but not cured by C. parvum was significantly slower than growth in untreated rats.

¹ Supported by National Cancer Institute Contract N01-CB-33891, Grant P30-CA-18450, and by the Jake Gittlen Memorial Golf Tournament.

² To whom requests for reprints should be addressed.

³ Recipient of USPHS Research Career Development Award K04-CA-70948, National Cancer Institute.

Received 6/19/78. Accepted 9/13/78.