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Tumor Promotion and the Induction of Epidermal Ornithine Decarboxylase Activity in Mechanically Stimulated Mouse Skin¹

School of Biological Sciences, Flinders University of South Australia, Bedford Park, South Australia 5042

Wounding by incision was a promoting stimulus in mouse skin previously initiated with 7,12-dimethylbenz(a)anthracene. Skin massage elicited a marked proliferative response in skin but was not a promoting stimulus.

Wounding mouse skin, either by multiple scalpel incisions or by stripping with silicon carbide paper, led to a marked induction of ornithine decarboxylase activity. In both instances activity was maximal between 20 and 26 hr after wounding, with a secondary rise at 72 hr. Skin massage did not lead to a detectable increase in ornithine decarboxylase activity over the same time period.

¹ This work was supported by the Australian Research Grants Committee and the Australian Tobacco Research Foundation.

² To whom requests for reprints should be addressed.

Received 8/ 2/77. Accepted 11/23/77.