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Effects of Hyperthermia on Primary and Metastatic Tumor Growth and Host Immune Response in Rats

Radiobiology Division, Department of Radiology, New York Medical College, New York, New York 10029

A hot water bath was used to heat locally a metastasizing carcinoma in Wistar/Furth rats. Applying heat such that intratumor temperature is maintained at a mean value of 42.3° for two 90-min sessions results in a decreased growth rate of the primary tumor as well as distant metastases. Heating the primary tumor for only one 90-min session or heating the leg contralateral to the tumor-bearing limb has no effect on the growth rate of either the primary tumor or metastases. Heat therapy has no detrimental effect on the spleen cell-mediated tumor immune response of rats as tested by an in vitro lymphocytotoxicity assay 1 day later. However, heating isolated spleen cells to similar temperatures in vitro reduces their capacity for in vitro tumor cell killing.

¹ American Cancer Society Clinical Fellow, Division of Radiation Oncology.

² To whom requests for reprints should be addressed.

Received 6/ 9/77. Accepted 11/23/77.

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