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A Cancer-associated, Fast, Homoarginine-sensitive Electrophoretic Form of Serum Alkaline Phosphatase

Departments of Physiological Chemistry [S. L. E., L. K.,R. L. M.], Statistics [B. L. J.], and Medicine and Pathology [F. C. L.], University of Wisconsin, Madison, Wisconsin 53706

Serum from patients with a variety of cancers often (p = 70%) contains a characteristic electrophoretic form of alkaline phosphatase detectable by cellulose polyacetate electrophoresis. The lower prevalence of this electrophoretic form in presumably healthy individuals (p = 7%) and noncancer hospitalized patients (p = 30%) suggests that it may be useful as a diagnostic or monitory marker.

¹ Authors listed in alphabetical order.

² To whom requests for reprints should be addressed, at Department of Physiological Chemistry, University of Wisconsin Center for Health Sciences, 1215 Linden Drive, Madison, Wis. 53706.

Received 8/18/77. Accepted 12/ 8/77.