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Differential Sensitivities of Five Rat Hepatoma Cell Lines to Anticancer Drugs¹

Department of Human Biological Chemistry and Genetics, Division of Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77550

Five permanent tumor cell lines derived originally from either a solid or an ascites biopsy of rat hepatoma exhibited differential sensitivities to bleomycin, Adriamycin, 1-ß-D-arabinofuranosylcytosine, hydroxyurea, 1-trans-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea, and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. The cells were least sensitive to hydroxyurea and 1-ß-D-arabinofuranosylcytosine, with some cell lines being almost totally resistant to these drugs. However, from 25- to 700-fold differences in survival were obtained between cell lines treated with either bleomycin or Adriamycin.

¹ Supported by NIH Grant 5 R01 CA 15397 (03) and CA 16663 (03).

Received 10/11/77. Accepted 12/ 8/77.