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Enhancement by Corynebacterium parvum of the Normal and Tumor Tissue Response to Hyperthermia¹

Edwin L. Steele Laboratory of Radiation Biology, Department of Radiation Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114

The effect of Corynebacterium parvum treatment on the response of tumor and normal tissue to hyperthermia (43.5°) was studied. Animals were C3Hf/Sed mice from our defined flora mouse colony. The time at hyperthermia that achieved control of one-half of methylcholanthrene-induced fibrosarcomas and the foot reaction were examined after treatment. C. parvum, if given 3 to 32 days before hyperthermia, enhanced the reaction to local hyperthermia of normal tissue. No enhancement was observed if C. parvum was given after hyperthermia. This enhancement was more dramatic for tumor response resulting in a therapeutic gain factor of 2.3 (3.7/1.6). Comparative studies on combined Corynebacterium and radiation failed to demonstrate the enhancement to normal tissue.

¹ Supported in part by NIH Grant CA 13311.

² To whom requests for reprints should be addressed.

³ Present address: Cancer Research Institute, Radiumstationen, 800 Aarhus C. Denmark.

⁴ Andres Soriano Director of Cancer Management, Massachusetts General Hospital.

Received 9/29/77. Accepted 12/29/77.