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Acceleration of Myeloid Recovery from Cyclophosphamide-induced Leukopenia by Pretreatment with Bacillus Calmette-Guérin¹

Pediatric Oncology [S. L., D. G. P.] and Medicine [J. M. B.] Branches, National Cancer Institute, Bethesda, Maryland 20014

Treatment of C57BL/6 mice with Bacillus Calmette-Guérin i.p. 8 days prior to the induction of leukopenia by cyclophosphamide (300 mg/kg i.p.) significantly (p < 0.002) increased peripheral granulocyte counts on each day during the recovery from leukopenia. The recovery of lymphocyte counts was unaffected by Bacillus Caimette-Guérin treatment. Further experiments indicated that the accelerated granulocyte recovery was the result of an earlier initiation of the recovery process rather than of the release of stored granulocytes. Bacillus Calmette-Guérin may have clinical value as a stimulator of myelopolesis in patients rendered leukopenic by antineoplastic chemotherapy.

¹ Presented in part at the 1977 American Federation for Clinical Research National Meeting, Washington, D. C., April 30 to May 2, 1977 (5).

² To whom requests for reprints should be addressed, at Building 10, Room 3B03, NIH, Bethesda, Md. 20014.

Received 10/ 3/77. Accepted 12/29/77.