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Marked Stimulation of Lymphocyte-mediated Attack on Tumor Cells by Target-directed Liposomes Containing Immune RNA

Division of Allied Health and Life Sciences, The University of Texas at San Antonio, San Antonio, Texas 78285 [W. E. M., J. H. C.], and Department of Microbiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 [D. E. T.]

A marked stimulation of normal guinea pig lymphocytes was obtained by incubating them with liposomes that contained both antibody to lymphocytes to provide "homing" of the vesicies and immune RNA isolated from guinea pigs immunized with syngeneic line 10 hepatocarcinoma cells. Tumor cell cytotoxicity was monitored by a ⁵¹Cr release assay. This target cell delivery of immune RNA by liposomes produced a dose-dependent stimulation up to 12 times that achieved by in vitro methods with naked immune RNA.

Received 10/12/77. Accepted 1/27/78.