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Prevalence of Non-T-Cells in the Replication of the N-tropic, Type C Virus of Young AKR Mice¹

Laboratoire d'Immunologie et de Virologie des Tumeurs (INSERM U 152), Hôital Cochin, 27 rue du Faubourg Saint Jacques, 75674 Paris Cedex 14, France

The XC infectious center assay was used to study the nature of the lymphoid cells producing N-tropic C-type viruses in preleukemic AKR mice. Viral production by thymic cell suspensions was very low and was possibly due to contaminating cells. Production at least 100-fold higher was found in spleen cells and was probably due to non-T-cells. The significance of these results is discussed briefly, including the possibility that the N-tropic XC syncitia-inducing type C virus of young AKR mice is not the leukemogenic agent.

¹ This work was supported by Institut National de la Santé et de la Recherche Médiclae Grant ATP 50.77 82 No. 20.

² To whom requests for reprints should be addressed.

³ The abbreviation used is: MuLV, murine leukemia virus.

Received 9/26/77. Accepted 1/10/78.