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Increased Susceptibility to Feline Leukemia Virus Infection in Cats Exposed to Methylnitrosourea¹

Departments of Veterinary Pathobiology [J. P. S., L. E. M., E. A. H., A. K., R. G. O.] and Microbiology [L. E. M., R. G. O.], Ohio State University, and Comprehensive Cancer Center [R. G. O.], Columbus, Ohio 43210

Exposure of adult specific-pathogen-free cats to methylnitrosourea resulted in increased susceptibility to infection by feline leukemia virus. A greater proportion of cats exposed to methylnitrosourea and feline leukemia virus (69%) became persistently viremic than those exposed to feline leukemia virus alone (17%). Segmented neutrophils were reduced by 90 to 99% within 3 days following exposure to methylnitrosourea, (15 to 20 mg/kg) whereas the effects on lymphocytes and erythrocytes, although less obvious, were also detected.

¹ Supported in part by Contract 1 CP 53571 within the Virus Cancer Program of the National Cancer Institute, NIH, USPHS, and by a Biomedical Research Support Grant 5 SO7 RR05463-14 within the Division of Research Resources, Department of Health, Education and Welfare USPHS, NIH.

Received 6/21/77. Accepted 1/ 5/78.