This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Flora, K. P. Articles by Wampler, G. L. Search for Related Content PubMed PubMed Citation Articles by Flora, K. P. Articles by Wampler, G. L.

Antitumor Activity of Amidoximes (Hydroxyurea Analogs) in Murine Tumor Systems¹

Departments of Pharmaceutical Chemistry [K. P. F., B. V. R.] and Medicine [G. L. W.], Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298

A series of amidoximes was prepared and evaluated for possible antitumor activity against L1210 leukemia. Three of the most active compounds in the L1210 system, formamidoxime, acetamidoxime, and 2-aminoacetamidoxime hydrochloride, were also active against P388 leukemia. Acetamidoxime was marginally active against Lewis lung carcinoma. The active amidoximes showed best activity against L1210 leukemia when given two times daily, 5 hours apart, for 8 days. Most of the amidoximes produced excessive central nervous system stimulation.

¹ This work was supported by Grant CA 10572 from the National Cancer Institute and Grant IN-105 from the American Cancer Society.

² Present address: Pharmaceutical Resources Branch, National Cancer Institute.

³ To whom requests for reprints should be addressed, at Box 292, MCV Station, Richmond, Va. 23298.

Received 5/ 3/77. Accepted 2/ 3/78.