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Modulatory Effect of the Sympathetic Nervous System on Neuroblastoma Tumor Growth¹

Department of Neurology, University of Chicago, and the Pritzker School of Medicine, Chicago, Illinois 60637

Growth of C-1300 neuroblastoma was markedly suppressed in mice chemically sympathectomized at birth with 6-hydroxydopamine. Growth of A-10 adenocarcinoma was also somewhat reduced.

In newborn mice pretreated with nerve growth factor to induce sympathetic nervous system neuronal hypertrophy, neuronal maturation, and peripheral hyperinnervation, the growth of neuroblastoma was augmented.

¹ Supported by Grant MS:5-RO1 CA21043-02, NIH.

² To whom requests for reprints should be addressed, at Department of Neurology, University of Chicago, Pritzker School of Medicine, Division of the Biological Sciences, 950 East 59th Street, Chicago, Ill. 60637.

Received 11/14/77. Accepted 2/13/78.