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Effects of Dietary Constituents on Ultraviolet Light-mediated Carcinogenesis¹

Photobiology Laboratory, Veterans Administration Hospital [H. S. B., J. T. C., G. E. B.], and Departments of Dermatology [H. S. B., J. T. C., G. E. B.] and Biochemistry [H. S. B.], Baylor College of Medicine, Houston, Texas 77030

The effects of several dietary supplements of antioxidants and enzyme inducers on ultraviolet light-mediated carcinogenesis were investigated. Glutathione (reduced) was without effect, but butylated hydroxytoluene, phenobarbital, and disulfiram all significantly suppressed the initiation and development of actinic lesions and tumors. On the basis of the present study and related previous ones, tumor inhibition appears to be due not to an umbrageous effect but rather to the induction of systemic physiological responses.

¹ Supported by USPHS Grant CA 13464-06 from the National Cancer Institute.

² To whom requests for reprints should be addressed.

³ Present address: Department of Biology, Texas Southern University, Houston, Texas 77004.

Received 10/17/77. Accepted 2/10/78.

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