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Inability of Vitamin A Deficiency to Alter Benzo(a)pyrene Metabolism in Syrian Hamsters¹

Department of Biochemistry, The University of Vermont College of medicine, Burlington, Vermont 05401 [W. A. B., M. P. L., A. H. L. C., E. B.], and Department of Nutritional and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 [R. L. G., P. M. N.]

Syrian golden hamsters were placed on a control or vitamin A-deficient diet. When their serum vitamin A content was significantly reduced, i.e., to less than 10% of controls, the hamsters were killed and lung aryl hydrocarbon hydroxylase activity and metabolism of benzo(a)pyrene were determined. The benzo(a)pyrene metabolite profile was similar with control and A-deficient systems, and only few quantitiative differences were noted. Addition of ß-retinyl acetate to the in vitro incubations did not substantially affect benzo(a)pyrene metabolism.

¹ Supported in part by National Cancer Institute Grant CA 20711.

² This work comprises part of the Ph.D. dissertation to be submitted to the Graduate School, Medical College of Georgia.

Received 11/10/77. Accepted 2/22/78.