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Induction of Spleen Cell Growth and DNA Polymerase Activity by Corynebacterium parvum¹

Departments of Radiation Medicine [Y. M.] and Biochemistry [M. S. C.], University of Kentucky Medical Center, Lexington, Kentucky 40506

Corynebacterium parvum Induces rapid proliferation of spleen cells with concomitant rapid increases in DNA synthesis as measured by [³H]thymidine uptake and increase in DNA polymerase activity. Cell number increased exponentially over 10 days. DNA polymerase activity increased 8-fold after C. parvum stimulation. The rapidity of response indicated a population response to the stimulus, and the data are consistent with a direct stimulation of spleen cell proliferation by C. parvum.

¹ Supported in part by USPHS Research Grants RO1-CA-13849, PO1-CA-17786, and Ro1-CA-19492 from the National Cancer Institute, NIH.

Received 7/22/77. Accepted 3/ 9/78.