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Induction of Peripheral Neuroblastomas in Syrian Hamsters after Injection as Neonates with JC Virus, a Human Polyoma Virus¹

Departments of Pathology [J. V., G. M. Z.] and Medical Microbiology [B. L. P., D. L. W.], University of Wisconsin Medical School, Madison, Wisconsin 53706

Neuroblastomas developed in 10 of 31 Syrian hamsters inoculated intraocularly with JC virus, a human polyoma virus. The latent period was 6 to 11 months. Primary tumors occurred in the abdominal cavity, pelvis, mediastinum, and neck region. The origin of one tumor from the adrenal gland was demonstrated. Metastases were seen in the liver, bone marrow, and lymph nodes.

Two neuroblastomas arising in this experiment were transplanted serially in weanling hamsters, and a tissue culture cell line was established from one of the transplanted tumors. T-antigen was detected in three of five primary tumors tested and in the transplanted tumors. Antibody against T-antigen was demonstrated in sera from five of six animals with neuroblastomas.

Neuroblastomas also developed after combined s.c. and i.p. injection of JC virus.

¹ This investigation was supported by USPHS Research Grants NS-11129 and AI-11217. Part of this study was presented at the 52nd Annual Meeting of the American Association of Neuropathologists, San Francisco, Calif., June 11 to 13, 1976 (9).

² Present address: Department of Pathology, University of South Alabama, Mobile, Ala. 36688.

³ To whom requests for reprints should be addressed.

Received 1/16/78. Accepted 3/14/78.

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