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Interactions between Polonium-210 -Radiation, Benzo(a)pyrene, and 0.9% NaCl Solution Instillations in the Induction of Experimental Lung Cancer¹

Department of Physiology, Harvard University School of Public Health, Boston, Massachusetts 02115

Benzo(a)pyrene and ²¹⁰Po were administered both simultaneously and sequentially by intratracheal instillations to Syrian golden hamsters in experiments designed to identify any synergistic interactions between these carcinogens. Their effects were additive after simultaneous administration. A significant synergistic interaction between the two agents appeared to occur when benzo(a)pyrene exposure followed 4 months after ²¹⁰Po exposure. Most of this effect could be ascribed, however, to a potentiating effect of subsequent 0.9% NaCl solution instillations on ²¹⁰Po carcinogenesis. These results emphasize the fact that seemingly innocuous stimuli may significantly potentiate lung carcinogenesis. The implications of these findings in terms of the interactions between -radiation and cigarette smoke in human populations are discussed.

¹ Supported by Contract NO1-CP-33273 from the National Cancer Institute and Center Grant ES-00002 from the National Institute of Environmental Health Sciences.

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