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Soluble Suppressor Factor from the Spleens of Tumor-bearing Mice¹

Departments of Surgery [S. Y., C. F. M.] and Microbiology [C. S., C. F. M.], University of Minnesota, Minneapolis, Minnesota 55455

Spleen cells from tumor-bearing mice when cultured for 3 to 5 days released a soluble factor into the media that suppressed the stimulation of lymph node and spleen cells by tumor antigen or mitogens. Spleens from mice bearing MC43 tumors for 14 days were capable of producing suppressor factor in vitro, while those from mice bearing the tumor for 10 days or less failed to do so. Lymph node cells from the same animals did not produce suppressor factor in vitro. The suppressor factor was produced by a nonadherent cell population, was heat stable, was lost on dialysis, and did not appear to be tumor antigen or thymidine.

¹ Presented in part at the Annual Meeting of the American Association of Immunologists, Chicago, Ill., April 1977 (18). Supported by American Cancer Society Grant IM-251, USPHS Grant RO1-CA-19510-01, and the J. Ernest Ayre Fund from the National Cancer Cytology Center, Melville, N. Y.

² To whom requests for reprints should be addressed, at University of Minnesota, Department of Surgery, Box 85; Mayo Memorial Bldg., Minneapolis, Minn. 55455.

Received 8/18/77. Accepted 4/ 4/78.