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Increased Activity of Rat Liver Messenger RNA and of Albumin Messenger RNA Modulated by Thioacetamide

Laboratory of Pathophysiology, National Cancer Institute, NIH, Bethesda, Maryland 20014

Administration of thioacetamide to rats was found to increase the activity of liver messenger RNA in the wheat germ protein synthesis assay. The synthesis of total protein was increased about 2.5-fold after 4 days of treatment. The treatment was associated with an increase in the relative quantity of polyadenylic acid-containing RNA. Immunoprecipitation studies showed that albumin synthesis directed by the messenger RNA was increased disproportionately, reaching a level 5 to 6 times the control after 4 days of thioacetamide administration.

Received 1/23/78. Accepted 3/28/78.

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