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Oncogenicity of Purine 3-Oxide and Unsubstituted Purine in Rats¹

Walker Laboratory, Sloan-Kettering Institute for Cancer Research, Rye, New York 10580 [M. N. T., A. G-S., G. S., G. B. B.], and Lawrence Hospital, Bronxville, New York 10708[J. M. B.]

Injection s.c. of purine 3-oxide into Wistar rats resulted in the appearance of sarcomas and fibromas at the interscapular site of administration, carcinomas in the liver, and a high incidence of s.c. fibromas in the hip at a distance from the site of injection. A small number of liver tumors but no tumors at the injection site appeared in rats to which the parent compound, purine, was administered. Oxidation of purine 3-oxide by xanthine oxidase was found to occur in two steps to yield the potent oncogen 3-hydroxyxanthine. A similar process may occur in vivo since a protein preparation from rat s.c. tissue has similar oxidizing activity.

¹ This work was supported in part by USPHS Research Grants CA 08748, CA 15274, and CA 17085 from the National Cancer Institute. Presented in part at the 67th Annual Meeting of the American Association for Cancer Research, Inc., Toronto, Canada, May 1976 (5). This is Contribution 69 in a series on purine N-oxides.

² To whom requests for reprints should be addressed.

Received 2/10/78. Accepted 4/27/78.

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