This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Vaage, J. Articles by Reinertsen, J. L. Search for Related Content PubMed PubMed Citation Articles by Vaage, J. Articles by Reinertsen, J. L.

Effect of Progressive Neoplastic Growth on the Decarboxylation of DL-[1-¹⁴C]Ornithine by Lymphocytes from C3H/He Tumor Hosts¹

Department of Cancer Therapy Development, Pondville Hospital, Walpole, Massachusetts 02081 [J. V.]; Department of Surgery, Georgetown University Hospital, Washington, D. C. 20007 [S. A.]; and Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, NIH, Bethesda, Maryland 20014[J. L. R.]

The reactivity of normal and tumor host lymphocytes incubated with normal serum or with serum or malignant ascites fluid from tumor hosts was measured by the ability of the lymphocytes to synthesize ornithine decarboxylase after phytohemagglutinin stimulation. Each of three tumors tested (a solid fibrosarcoma, an ascites mammary carcinoma, and an ascites ovarian carcinoma) caused increasing unresponsiveness in the lymphocytes of mice with progressing syngeneic neoplastic growth. The sera and particularly the malignant ascites fluids from mice given implants of the ascites cancers became progressively inhibitory to the activation of lymphocytes from tumor hosts as well as from normal mice. The serum from mice carrying s.c. implants of the fibrosarcoma enhanced the activation of lymphocytes from tumor hosts and from normal mice during early tumor growth before it also became inhibitory.

¹ This work was supported by USPHS Grants CA-15960 and CA-16039.

² To whom requests for reprints should be addressed.

³ Recipient of Research Fellowship CA-05086 awarded by the National Cancer Institute, Department of Health, Education and Welfare.

Received 12/12/77. Accepted 4/27/78.