This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Shoemaker, J. P. Search for Related Content PubMed PubMed Citation Articles by Shoemaker, J. P.

Fifty-five Percent Complete Remission of Mammary Carcinoma in Mice with 5-Fluorouracil and Chloroquine

Research Service, Veterans Administration Hospital, and Department of Surgery, School of Medicine, Marshall University, Huntington, West Virginia 25701

Injection of 5-fluorouracil (5-FUra) [12 mg/kg i.p. (0.1 ml) every other day] and chloroquine phospate (CP) [10 mg/kg i.p. (0.1 ml) daily] after the 19th day postimplant brought about a 55% complete remission of mammary carcinoma (C3HBA) in 2 separate experiments. FUra used alone brought about 40% complete tumor remissions, whereas CP used alone resulted in 30% complete remissions. None of these tumors reappeared before 189 days postimplant in Experiment 1 and 120 days postimplant in Experiment 2.

The 5-FUra + CP treatment showed statistically (P < 0.05) smaller tumor sizes compared to control mice tumor sizes on each of 13 check days after treatment was begun. The CP-treated tumors were statistically smaller than the control tumors on 10 check days, whereas the 5-FUra-treated tumors were smaller than the control tumors on 9 check days. The 5-FUra-treated tumors were statistically smaller than the CP-treated tumors on 2 check days (23 and 33). The 5-FUra + CP-treated tumors were statistically smaller than the CP-treated tumors on 3 check days (36, 43, and 47), and the 5-FUra + CP-treated tumors were statistically smaller than the 5-FUra-treated tumors on the last 4 check days (54, 57, 61, and 64).

¹ Supported by the Veterans Administration Research Service Cost Center 104.

Received 8/ 8/77. Accepted 5/30/78.