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Appearance of Intestinal Type of Tumor Cells in Hepatoma Tissue Induced by 3'-Methyl-4-dimethylaminoazobenzene¹

Department of Pathology, Sapporo Medical College, S1 W17 Chuo-ku, Sapporo, Hokkaido 060, Japan

Carcinoma tissues induced by 3'-methyl-4-dimethylaminoazobenzene were investigated both morphologically and biochemically. The most prominent histological pattern was an undifferentiated carcinomatous one. While this type of carcinoma, histologically, appeared to be due to a uniform population of cells, electron microscopic examination revealed that the carcinoma tissue was composed of many types of cells including cells that contained either the brush border or the mucous droplets seen in goblet cells. In addition, tumor cells that contain serotonin-like granules were noticed.

An electrophoretogram of alkaline phosphatase in the tissue extract of this type of carcinoma revealed distinctly the presence of its intestinal isozyme. These findings evidently show that carcinoma induced by 3'-methyl-4-dimethylaminoazobenzene includes in addition to the cells differentiated toward hepatocytes or cholangiolar cells, those differentiated toward intestinal epithelial cells.

¹ This research was supported in part by Grant-in-Aid form Cancer Research 201002 from the Ministry of Education, Science, and Culture, Japan.

² Present address: La Jolla Cancer Research Foundation, 417 Coast Boulevard South, P. O. Box 1376, La Jolla, Calif. 92038. To whom requests for reprints should be addressed.

Received 1/ 6/78. Accepted 5/30/78.

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