This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gomer, C. J. Articles by Dougherty, T. J. Search for Related Content PubMed PubMed Citation Articles by Gomer, C. J. Articles by Dougherty, T. J.

Determination of [³H]- and [¹⁴C]Hematoporphyrin Derivative Distribution in Malignant and Normal Tissue¹

Department of Radiation Medicine, Roswell Park Memorial Institute, Buffalo, New York 14263

The synthesis and tissue-localizing ability of [¹⁴C]- and [³H]hematoporphyrin derivative (HPD) in mice have been described. Tissue levels and distributions were the same for both radioactive compounds, indicating that in vivo tritium exchange did not occur with [³H]HPD. The amount of [¹⁴C]HPD or [³H]HPD which localized in the transplanted tumor tissue of mice at various times following i.p. injection (10 mg/kg) was higher than in skin or muscle tissue but was less than in liver, kidney, or spleen tissue. These results tend to disprove the generalization that HPD accumulates in malignant tissue to a higher degree than in all normal tissue. It is also reported that gross visualization of porphyrin fluorescence cannot be correlated with actual tissue concentrations of the dye.

¹ This work was supported in part by Institutional Research Grant IN-54-0-23 of the American Cancer Society; Biomedical Research Support Grants RR-05648-10 and RR-05648-11 of the NIH; and NIH Grants CA-16717 and CA-17609.

² Present address: Mammalian Biology Group, Los Alamos Scientific Laboratory, Los Alamos, N. M. 87545.

³ To whom requests for reprints should be addressed.

Received 6/19/78. Accepted 10/ 4/78.

This article has been cited by other articles:

				S. M. Hahn, D. L. Fraker, R. Mick, J. Metz, T. M. Busch, D. Smith, T. Zhu, C. Rodriguez, A. Dimofte, F. Spitz, et al. A Phase II Trial of Intraperitoneal Photodynamic Therapy for Patients with Peritoneal Carcinomatosis and Sarcomatosis Clin. Cancer Res., April 15, 2006; 12(8): 2517 - 2525. [Abstract] [Full Text] [PDF]

				E. Crescenzi, A. Chiaviello, G. Canti, E. Reddi, B. M. Veneziani, and G. Palumbo Low doses of cisplatin or gemcitabine plus Photofrin/photodynamic therapy: Disjointed cell cycle phase-related activity accounts for synergistic outcome in metastatic non-small cell lung cancer cells (H1299). Mol. Cancer Ther., March 1, 2006; 5(3): 776 - 785. [Abstract] [Full Text] [PDF]

				A. Ernst, D. Feller-Kopman, H. D. Becker, and A. C. Mehta Central Airway Obstruction Am. J. Respir. Crit. Care Med., June 15, 2004; 169(12): 1278 - 1297. [Abstract] [Full Text] [PDF]

				J. S. Friedberg, R. Mick, J. P. Stevenson, T. Zhu, T. M. Busch, D. Shin, D. Smith, M. Culligan, A. Dimofte, E. Glatstein, et al. Phase II Trial of Pleural Photodynamic Therapy and Surgery for Patients With Non-Small-Cell Lung Cancer With Pleural Spread J. Clin. Oncol., June 1, 2004; 22(11): 2192 - 2201. [Abstract] [Full Text] [PDF]

				E. Crescenzi, L. Varriale, M. Iovino, A. Chiaviello, B. M. Veneziani, and G. Palumbo Photodynamic therapy with indocyanine green complements and enhances low-dose cisplatin cytotoxicity in MCF-7 breast cancer cells Mol. Cancer Ther., May 1, 2004; 3(5): 537 - 544. [Abstract] [Full Text] [PDF]

				R. J. Canter, R. Mick, S. B. Kesmodel, D. J. Raz, F. R. Spitz, J. M. Metz, E. J. Glatstein, S. M. Hahn, and D. L. Fraker Intraperitoneal Photodynamic Therapy Causes a Capillary-Leak Syndrome Ann. Surg. Oncol., June 1, 2003; 10(5): 514 - 524. [Abstract] [Full Text] [PDF]

				T. W. Bauer, S. M. Hahn, F. R. Spitz, A. Kachur, E. Glatstein, and D. L. Fraker Preliminary Report of Photodynamic Therapy for Intraperitoneal Sarcomatosis Ann. Surg. Oncol., April 1, 2001; 8(3): 254 - 259. [Abstract] [Full Text] [PDF]

				L. M. Seijo and D. H. Sterman Interventional Pulmonology N. Engl. J. Med., March 8, 2001; 344(10): 740 - 749. [Full Text] [PDF]

				S. K. Hendren, S. M. Hahn, F. R. Spitz, T. W. Bauer, S. C. Rubin, T. Zhu, E. Glatstein, and D. L. Fraker Phase II Trial of Debulking Surgery and Photodynamic Therapy for Disseminated Intraperitoneal Tumors Ann. Surg. Oncol., January 1, 2001; 8(1): 65 - 71. [Abstract] [Full Text] [PDF]

				B. W. Engbrecht, C. Menon, A. V. Kachur, S. M. Hahn, and D. L. Fraker Photofrin-mediated Photodynamic Therapy Induces Vascular Occlusion and Apoptosis in a Human Sarcoma Xenograft Model Cancer Res., September 1, 1999; 59(17): 4334 - 4342. [Abstract] [Full Text] [PDF]