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Banding Studies of Chromosomal Abnormalities in Patients with Acute Lymphocytic Leukemia¹

Departments of Medicine [M. C. C., J. D. R., A. K., H. M. G.] and Pathology [D. V.], University of Chicago Hospitals and Clinics, University of Chicago Cancer Research Center [H. M. G.], and The Franklin McLean Memorial Research Institute [J. D. R.], ⁴ Chicago, Illinois 60637

Karyotypes were analyzed by routine Giemsa and quinacrine fluorescence for 16 patients with acute lymphocytic leukemia [ten adults (18 to 51 years) and six children (3 to 15 years)]. Four patients had received previous therapy, but all 16 had active disease when they were first studied. Eight patients (five untreated) had a normal karyotype initially; however, three of these developed a chromosomal abnormality during relapse. Eight patients had a chromosomal abnormality in their initial samples. Each of the 11 patients had different abnormalities. All chromosomes except Nos. 3, 5, 15, 16, and Y were involved in the various aneuploidies. One patient had a Ph¹ chromosome due to a translocation with No. 21: t(21;22)(q22;q11). A patient with B-cell acute lymphocytic leukemia had a 14q+ marker in addition to other abnormalities. The median survival of patients with initially normal karyotypes may be longer than that of patients whose karyotypes are abnormal initially.

¹ Supported in part by NIH Grants CA 19266 and CA 16910 and by an Otho S. A. Sprague Memorial Institute Grant.

² To whom requests for reprints should be addressed, at Department of Medicine, The Pritzker School of Medicine, University of Chicago, Box 420, 950 East 59th Street, Chicago, Ill. 60637.

³ Present address: The Professional Building, 800 Austin Street, Evanston, Ill. 60202.

⁴ Operated by the University of Chicago for the United States Department of Energy under Contract EY-76-C-02-0069.

Received 8/21/78. Accepted 10/18/78.