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In Vivo Autoradiography and Nitrosoheptamethyleneimine Carcinogenesis In Hamsters¹

Chemical Carcinogenesis Program, NCI-Frederick Cancer Research Center, Frederick, Maryland 21701³

Quantitative autoradiograms were made, in vivo, in European hamsters with the use of [¹⁴C]nitrosoheptamethyleneimine (260 µCi/animal; time between administration of nitrosamine and killing of animals, 6 hr). In this species, the lung is the principal target, and radioactivity was found in the Clara cells of the bronchial epithelium and in the nitrosoheptamethyleneimine-induced tumors which derive from these cells.

Tumors are not induced in the liver, which can metabolize this compound, and labeling is found principally in the cytoplasm, whereas in the target cells there is a high degree of labeling in both the cytoplasm and the nuclei.

¹ Supported in part by USPHS Contract N01-CP-12148 from the Division of Cancer Cause and Prevention, National Cancer Institute.

² To whom requests for reprints should be addressed.

³ The animal experiments were done at the section of experimental pathology, Medical School, Hannover, Federal Republic of Germany.

Received 6/21/78. Accepted 10/ 9/78.