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Hormonally Induced Tumors of the Reproductive System of Parabiosed Male Rats¹

Cancer Research Institute, New England Deaconess Hospital [C. E. B., S. W., R. N. C.], and Laboratory of Human Reproduction and Reproductive Biology, Harvard University [K. J. R., R. B. T.], Boston, Massachusetts 02215

Parabiosis of intact male rats to castrated males or oophorectomized females for a period of approximately 20 months resulted in three interstitial cell tumors of the testis. When unilateral nephrectomy was added to the parabiotic procedure in ten pairs, eight interstitial cell tumors of the testis and four adenocarcinomas of the prostate occurred in the target male parabionts. These changes were preceded by elevations in luteinizing and follicle-stimulating hormone levels in the serum of the castrates and high levels of testosterone and, to a lesser degree, of androstenedione in the target partners developing the tumors.

¹ This investigation was supported by United States Department of Energy Contract EY-76-S-02-3017.A004 with the New England Deaconess Hospital and by Grant CA 24893 awarded by the National Cancer Institute, Department of Health, Education and Welfare. This is Article 648 from the Cancer Research Institute of the New England Deaconess Hospital.

² To whom requests for reprints should be addressed, at Cancer Research Institute, New England Deaconess Hospital, 185 Pilgrim Road, Boston, Mass. 02215.

Received 6/ 4/79. Accepted 7/11/79.

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