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Effects of Systemic Acidification of Mice with Sarcoma 180¹

Department of Medicine A [S. H., E. S. H., C. N.], and Computer Center [C. N.], Roswell Park Memorial Institute, Buffalo, New York 14263

The effects of dietary-induced acidosis on the growth and rates of complete regression of Sarcoma 180 in mice have been studied. The experiments here reported have demonstrated that mineral acidification of laboratory food produces a late decrease in tumor growth and significantly increases the rates of complete tumor regression. Blood acid-base studies also demonstrate the effects of these diets in altering the acid-base balance, and seemingly, this is independent of starvation and/or ketosis. The relationships of such in vivo acid-base metabolic changes to the control of tumor metabolism are briefly discussed. A therapeutic potential for this preliminary approach is considered.

¹ This research was supported in part by USPHS Grants CA-5834 and CA-09108 from the National Cancer Institute.

² To whom requests for reprints should be addressed, at Department of Thoracic Surgery, Roswell Park Memorial Institute, 666 Elm Street, Buffalo, New York 14263.

Received 6/30/78. Accepted 7/30/79.

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