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Relationship between Inhibition of Protein Methylase I and Inhibition of Rous Sarcoma Virus-induced Cell Transformation¹

Institut de Chimie des Substances Naturelles, Centre National de Recherche Scientifique, 91190 Gif-sur-Yvette, France

A correlation was found between inhibition of protein methylase I and inhibition of virus-induced cell transformation by structural analogs of S-adenosylhomocysteine; all good inhibitors of this enzyme are also good inhibitors of Rous sarcoma virus-induced chick embryo fibroblast transformation.

The inhibitory effect of these analogs was similar on enzymes from normal and transformed cells; no significant variation of the inhibition constants was observed after purification of protein methylase I.

From the kinetic constants obtained, a structure-activity relationship can be established for protein methylase I.

¹ This work was supported in part by grants from the Institut Pasteur, Paris; the Ligue Nationale Française contre le Cancer; INSERM, ATP 52-77; and the Fondation pour la Recherche Medicale Française.

² To whom requests for reprints should be addressed.

Received 11/28/78. Accepted 8/10/79.

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