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Effect of Catechol Estrogens on Rat Mammary Tumors¹

College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455

The effect of 1,3,5(10)-estratriene-3,16,17ß-triol (estriol), 1,3,5(10)-estratriene-2,3-diol-17-one (2-hydroxyestrone), and 1,3,5(10)-estratriene-2,3,17ß-triol (2-hydroxyestradiol) on the growth of dimethylbenz(a)anthracene-induced mammary tumor and of R3230AC-transplantable mammary tumor was compared with that produced by estradiol benzoate treatment. Estriol showed minimal inhibition of tumor growth in dimethylbenz(a)anthracene-induced tumor and no effect on R3230AC tumor while 2-hydroxyestrone showed no effect of tumor inhibition. On the other hand, 2-hydroxyestradiol showed appreciable inhibition of tumor growth in both tumors studied. That 2-hydroxyestradiol has been found to bind to estrogen receptors in mammary tumors and is uterotropic suggests that the inhibition of tumor growth by 2-hydroxyestradiol may be similar to the mechanism of inhibition of mammary tumors by high concentrations of estradiol.

¹ This work was partially supported by a grant from the Graduate School, University of Minnesota.

Received 6/12/78. Accepted 8/21/79.