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In Vivo Tumor Discrimination in a Rat by Proton Nuclear Magnetic Resonance Imaging¹

Department of Physics, University of Nottingham, University Park, Nottingham NG7 2RD, England

Transverse cross-sectional images which represent the spatial distribution of the proton nuclear magnetic resonance signal in a live Wistar rat have been produced by the multiple-sensitive-point method. The images form a chronological series demonstrating the detection and development of a D23 hepatoma in the abdomen. Discrimination of the tumor is by contrast with the surrounding tissue and is attributed to the elevated water content and relaxation times of the former.

¹ Supported by MRC Grant G975-102.

² Present address: Department of Physiological Chemistry, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Md. 21205. To whom requests for reprints should be addressed.

Received 8/11/78. Accepted 11/ 3/78.

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