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Monitoring of Antitumor Immunity in Patients with Larynx Cancer by Tube Leukocyte Adherence Inhibition Assay¹

Vladimír Holán², Otakar íbl and Milan Haek

Institute of Molecular Genetics, Czechoslovak Academy of Sciences, 166 10 Prague 6, Flemingovo nám. 2 [V. H., M. H.], and Clinic of Otorhinolaryngology, Institute for Postgraduate Education of Physicians and Pharmacists, Bulovka Hospital, 180 00 Prague 8, Budinova 2, Czechoslovakia [O. S.]

The presence of specific antitumor immunity was examined by the tube leukocyte adherence inhibition (LAI) assay in patients with carcinomas of the larynx. Peripheral blood leukocytes (PBL) from patients with larynx cancer gave positive reactions in the tube LAI assay with the antigen prepared from the carcinoma of the larynx but not with antigen from normal larynx tissue. Adherence of PBL from normal donors did not differ significantly irrespective of whether antigens from tumor or normal larynx tissue were used. With a panel of tumor extracts tested, PBL of some patients reacted to only one antigen, whereas PBL of other patients reacted to several antigens. LAI reactivity disappeared after surgery, reappeared at 4 weeks after surgery, and then declined when patients were tumor free. These results show that the tube LAI assay may be of value in diagnosing larynx cancer and in following up its treatment.

¹ Presented at the International Workshop on Leukocyte Adherence Inhibition, May 15 to 17, 1978, Buffalo, N. Y.

² Presenter. To whom requests for reprints should be addressed.