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Ascorbic Acid and Cancer: A Review¹

Vale of Leven Hospital, Loch Lomondside G83 0UA, Scotland [E. C.]; Linus Pauling Institute of Science and Medicine, Menlo Park, California 94025 [L. P.]; and Department of Pathology, University of Oregon Medical School, Portland, Oregon 97201 [B. L.]

Host resistance to neoplastic growth and invasiveness is recognized to be an important factor in determining the occurrence, the progress, and the eventual outcome of every cancer illness. The factors involved in host resistance are briefly reviewed, and the relationship between these factors and ascorbic acid metabolism is presented in detail. It is shown that many factors involved in host resistance to neoplasia are significantly dependent upon the availability of ascorbate.

¹ This study was supported by research grants from the Secretary of State for Scotland. The Educational Foundation of America. The Foundation for Nutritional Advancement, The Argyll and Clyde Health Board, Scotland, and by private donations to the Linus Pauling Institute of Science and Medicine.

Received 6/14/78. Accepted 12/ 4/78.

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