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Immunogenicity of Chemically Induced Murine Colon Cancers¹

Surgical Oncology Service, Department of Surgery, University of California, San Diego, School of Medicine, San Diego, California 92103

The antigenicity and immunogenicity of three colorectal carcinomas induced in BALB/c mice by 1,2-dimethylhydrazine or N-methyl-N-nitrosourethan were studied. All tumors were readily transplantable. Two of these tumors metastasized when transplants reached sufficient size. All tumors were found to be immunogenic in the strain of origin, and all tumors were shown to contain unique tumor-specific transplantation antigens in cross-protection experiments. The use of these tumors as an animal model for studies of adjuvant immunotherapy and chemoimmunotherapy is suggested.

¹ Supported in part by Grant CA-19087 from the NIH, USPHS, and International Research Fellowship TWO2458 from the Fogarty International Center, NIH.

² Present address: Department of Surgery, University of Utah Medical Center, Salt Lake City, Utah 84111.

³ To whom requests for reprints should be addressed, at University Hospital-H-891B, 225 Dickinson Street, San Diego, Calif. 92103.

Received 8/28/78. Accepted 12/21/78.