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Tumor Angiogenesis Activity in Clonal Cells Transformed by Bovine Adenovirus Type 3

Biological Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd., Osaka 532, Japan

Four different sets of clonal cells transformed by bovine adenovirus type 3 and its oncogenic DNA fragments, and their clonal normal counterparts, were tested for tumor angiogenesis activity. The activity was assayed by measuring the host-mediated vascular response of a chorioallantoic membrane to the cell suspension separated from the vascular bed by a Millipore filter. Angiogenesis activity due to inflammation reaction was prevented by using corticosteroids. All of the transformed cells tested induced strong vascular responses as compared with their corresponding clonal normal cells. Cell dose and time dependency for the expression of the activity were also shown.

Received 7/10/78. Accepted 1/12/79.