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Insulin and Glucagon Receptors in Morris Hepatomas of Varying Growth Rates¹

Department of Medicine, University of California Service, and the Metabolism Section, Veterans Administration Hospital, San Francisco, California 94121

The binding of both insulin and glucagon to receptors in plasma membranes from five hepatomas of varying growth rates was diminished when compared to plasma membranes from normal liver. Scatchard analyses of the binding data suggested that the decrease in glucagon binding was due to a decrease in binding capacity, whereas the decrease in insulin binding was due either to a decrease in binding affinity or to site-site interactions. The decreased binding of insulin, but not of glucagon, showed a significant correlation with increasing growth rate of the tumors. These data suggest, therefore, that decreased binding of insulin to receptors could be a feature of increasing growth rate in hepatomas.

¹ This research was supported by the American Cancer Society Grant BC-265 and NIH Grant CA-15979.

² Visiting Scientist, University of Catania, Italy.

³ Recipient of a Fulbright International Scholarship.

⁴ To whom requests for reprints should be addressed, at Cell Biology Research Laboratory, Mount Zion Hospital and Medical Center, Box 7921, San Francisco, Calif. 94120.

Received 10/ 6/78. Accepted 1/26/79.