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Kinetics of Cell Kill by Hyperthermia¹

Cancer Research, The Upjohn Company, Kalamazoo, Michigan 49001

A review of published reports showed that there was surprisingly good agreement between different authors on the heat sensitivity of a particular cell line. For several cell lines, there was a marked difference in the heat of inactivation above 43° (H = 148 kcal/mol) and below 43° (H = 365 kcal/mol). This may indicate different mechanisms of cell killing above and below this temperature. With all cell lines tested, M- and S-phase cells were much more heat sensitive than were G₁ or G₂ cells. The heat sensitivity of S-phase cells is in contrast to the resistance of these cells to X-rays. The effect of hyperthermia on cell progression is discussed. The possibility of greater sensitivity of neoplastic cells to hyperthermia as compared to normal cells seems very promising.

¹ Presented at the Conference on Hyperthermia in Cancer Treatment, September 15 and 16, 1978, San Diego, Calif.