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Regional Blood Flow in Human Tumors¹

Department of Radiotherapy, Middle Finland Central Hospital, 40620 Jyväskylä 62, Finland

Blood flow in 97 human tumor nodules, of which 31 were lymphomas, 31 were anaplastic carcinomas, and 35 were differentiated cancers, was measured using the ¹³³Xe clearance method. The lymphomas showed statistically higher blood flow [34.6 ± 21 (S.D.) ml/min/100 g] than did the anaplastic carcinomas (15.4 ± 11.4 ml/min/100 g; p < 0.001) and the differentiated cancers (22.8 ± 14.9 ml/min/100 g; p < 0.05). The size of the tumors did not correlate with the blood flow. In the group of differentiated cancers, the blood flow in nodules in areas of earlier irradiation was lower (9.0 ± 6.3 ml/min/100 g) than in nodules in intact regions (25.0 ± 14.5 ml/min/100 g; p < 0.05). Nodules in cicatricial areas after surgical operation had lower blood flow than did nodules in the intact areas, but the difference is not statistically significant. It is obvious that most human tumors have a considerably lower blood flow than what one would expect to find in the surrounding normal tissue.

¹ Presented at the Conference on Hyperthermia in Cancer Treatment, September 15 and 16, 1978, San Diego, Calif.