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Carcinoembryonic Antigen-like Substance Derived from Human Prostate¹

Department of Urologic Surgery, University of Minnesota College of Health Sciences, Minneapolis, Minnesota 55455 [R. D. W., D. L. B., A. Y. E.], and Hoffmann-LaRoche Cancer Diagnostic Research Laboratory, Nutley, New Jersey 07110 [A. D. M., J. P. V.]

Carcinoembryonic antigen-like substance, previously detected in large amounts in the medium from cultures of human prostatic epithelial cells, also is present in extracts of benign and malignant human prostate. By column chromatography, the prostate-derived carcinoembryonic antigen-like substance derived from cultured prostate is the same as that in tissue extracts and is distinctly different from colon-derived carcinoembryonic antigen. The molecular weight of prostate-derived carcinoembryonic antigen-like substance is estimated to be greater than 5 x 10⁵. Prostate-derived carcinoembryonic antigen-like substance may be a prostate-specific substance.

¹ Supported in part by USPHS Grants CA 13095 and CA 15551.

² Clinical Faculty Fellow of the American Cancer Society 1977 to 1980, to whom requests for reprints should be addressed.

Received 10/31/78. Accepted 3/23/79.