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Type C Retrovirus Activation and Possible Functions in the Normal and Tumor-bearing Host¹

Carcinogenesis Intramural Program, National Cancer Institute, Frederick Cancer Research Center, Frederick, Maryland 21701 [A. H., D. R. T., A. K. F.], and Biological Carcinogenesis Research Program, Frederick Cancer Research Center, Frederick, Maryland 21701 [O. S. W.]

The pathological consequences of tumor virus infection, transformation, and tumor development in certain experimental animals is a well-established and accepted fact. More recently, it has been suggested that these viruses may also have a physiological function participating in such processes as cellular differentiation, immune recognition, and embryogenesis. This paper delineates the current information giving some credence to physiological function for type C viruses.

¹ Presented at the Alcohol and Cancer Workshop, October 23 and 24, 1978, Bethesda, Md.

² To whom requests for reprints should be addressed, at National Cancer Institute, Frederick Cancer Research Center, Building 538, Room 200D, Frederick, Md. 21701.