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Forssman-like Antibody Levels in Sera of Patients with Lung Cancer¹

Sloan-Kettering Institute for Cancer Research, New York, New York 10021

Sera of normal individuals or patients with lung cancer were assayed for Forssman-like antibody by a quantitative and specific method using ethylenediaminetetraacetate-containing buffer to inactivate complement in the test serum. It was shown that although Forssman-like antibody levels were distributed widely, (a) the levels of young (20 to 45 years of age) normal subjects of Blood Groups A and AB were lower than those of Blood Groups O and B, (b) the levels of old (60 to 80 years of age) normal subjects were lower than those of young normal subjects of Blood Groups O and B, and (c) the levels of old lung cancer patients were lower when compared to agematched normal individuals of their blood group.

¹ Supported by NIH Grants CA-18488, CA-08748, CA-18856, NS-11457; American Cancer Society Grant IM-185; Memorial Sloan-Kettering Cancer Center Special Projects grant, and the Glenn Edward Fletcher Foundation.

² Present address: Department of Immunology, The Center for Adult Diseases, Osaka 537, Japan.

³ To whom requests for reprints should be addressed, at Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, N. Y. 10021.

Received 7/31/78. Accepted 4/17/79.