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Occurrence of a Low-Molecular-Weight Calcium-binding Protein in Neoplastic Liver¹

Animal and Cell Physiology Group, Division of Biological Sciences, National Research Council, Ottawa, Ontario, Canada K1A OR6

A calcium-binding protein was detected in the cytosol of Morris hepatomas 7288, 5123tc (h), 5123tc, and 7795. This protein could not be detected in adult Buffalo liver, 24-hr regenerating liver, or 18- to 20-day-old fetal liver. The amount of this protein present was not clearly related to the growth rate of the tumors studied, although there was more in a faster growing tumor (5123tc) than in the slowest (7795). The protein from the four tumors was apparently identical. The calciumbinding protein was heat stable and was not the calcium-dependent regulator of cyclic nucleotide phosphodiesterase. It had an apparent molecular weight of less than 12,500.

¹ NRCC No. 17561.

Received 12/11/78. Accepted 4/26/79.

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