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Incorporation of HLA Antigens into the Envelope of RNA Tumor Viruses Grown in Human Cells¹

Department of Microbiology, Harvard University School of Public Health, Boston, Massachusetts 02115

Virion antigens of feline leukemia virus are associated with HLA antigens in the membrane of human cells infected with the virus. Feline leukemia virus produced by these cells incorporates host membrane antigens into the virion envelope, making the virus susceptible to lysis by antisera directed to HLA or to uninfected cells plus complement.

¹ This work was supported by National Cancer Institute Grants CA-13885 and CA-18216, National Cancer Institute contracts CB-64001 and CP-81004, and American Cancer Society Grant DT-32.

² To whom requests for reprints should be addressed, at Department of Microbiology, Harvard University School of Public Health, 665 Hungtington Avenue, Boston, Mass. 02115.

Received 2/22/79. Accepted 5/31/79.

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