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Inhibition of Lymphocyte Function in Rats Fed High-Fat Diets¹

Cancer Research Program [G. M. K., G. F., R. E. L.], Biometrics Unit [A. A. L.], and Biomembrane Research Laboratory [S. S. A., Jr., M. M. K., P. B. M.], Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, and Collaborative Radiology Health Laboratory, Colorado State University, Fort Collins, Colorado 80523 [W. A. S.]

Concanavalin A-induced blastogenesis of spleen lymphocytes was significantly inhibited when lymphocytes from rats on a high-polyunsaturated-fat diet were compared to lymphocytes from rats on a low-fat diet. Responsiveness was dependent on source of serum since lymphocytes from rats fed a lowfat diet were suppressed in serum from rats fed a high-polyunsaturated-fat diet. Alternatively, lymphocytes from rats on a high-polyunsaturated-fat diet were more responsive in serum from low-fat-fed rats compared to their response in autologous serum. One of the inhibiting factors in serum was the lipoprotein fraction; however, rats on a high-polyunsaturated-fat diet probably had additional inhibitors in their serum. While tumor incidence was highest in rats with the least responsive lymphocytes and lowest in rats with the most responsive lymphocytes, the significance of the observation is not known.

¹ This project was supported in part by BRSG Grant S07 RR05538 awarded by the Biomedical Research Support Grant Program, Division of Research Resources, NIH.

² To whom requests for reprints should be addressed.

Received 3/12/79. Accepted 5/30/79.

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